Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.
Function
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the bzip_maf family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the GRIK1-AS2 gene, which is transcribed in an opposite orientation to this gene but does not encode a protein.
See also
- Small Maf (sMaf)
- Bach1-sMaf heterodimer
References
Further reading
External links
- BACH1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human BACH1 genome location and BACH1 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
